SUMMARY
Obstructive sleep apnea (OSA) is a common sleep disorder, indirectly and directly associated with occurrence of various cardiovascular diseases. New evidence explaining various patomechanisms connecting OSA and atherosclerosis is constantly growing. There arises a possibility of gut microbioma playing important role in this process.
This article focuses on the association of OSA and atherosclerosis and the interaction of gut microbioma in these processes. Gut dysbiosis could possibly represent another risk factor, and potential therapeutic target of cardiovascular diseases.
Keywords: gut microbiome, obstructive sleep apnea, intermittent hypoxia, atherosclerosis.
Lek Obz, 2021, 70,(6): 232-236
Alžbeta HLUCHÁŇOVÁ 1, Pavel ŠIARNIK 2, Žofia RÁDIKOVÁ 3, Stanislava KLOBUCKÁ 4, Branislav KOLLÁR 2
1 Neurologická klinika SZU a Univerzitnej nemocnice Bratislava, prednosta prof. MUDr. J. Benetin, PhD.
2 I. neurologická klinika Lekárskej fakulty Univerzity Komenského a Univerzitnej nemocnice Bratislava, prednosta prof. MUDr. P. Turčáni, PhD.
3 Ústav klinického a translačného výskumu, Biomedicínske centrum Slovenskej akadémie vied, Bratislava
4 Rehabilitačné centrum HARMONY, n.o., Bratislava
Cite:
HLUCHÁŇOVÁ A., ŠIARNIK P., RÁDIKOVÁ Ž., KLOBUCKÁ S., KOLLÁR B.: The role of gut microbiome in the pathogenesis of obstructive sleep apnea and atherosclerosis. Lek Obz, 2021, 70,(6): 232-236
