Chronický zápal a zmeny kostného tkaniva u pacientov s osteoartritídou a insuficienciou exokrinnej funkcie pankreasu

Liliya S. BABINETS, Iryna M. HALABITSKA

I. Horbachevsky Ternopil National Medical University, Ukraine

SUMMARY
Introduction. Osteoporosis is characterized by decreased bone density, micro-architectonic changes of bone tissue, which leads to bone fragility and increased risk of bone fracture. This is typically and often the only symptom of this disease. Analysis of bone density speed loss shows the difference of bone density in patient without chronic disorder and person with some chronic disease. It could be making the conclusion that chronic homeostasis imbalance due to any etiology has negative influence on bone tissue state. Chronic inflammatory process plays very important role in the development of primary osteoarthritis, which accelerates the progression of this disease.
The goal of research. Make complex study of bone density in patients with primary osteoarthritis and exocrine pancreatic insufficiency and patients with primary osteoarthritis without exocrine pancreatic insufficiency, analyze possible correlations between them.
Methods. There were examined 112 patients with primary osteoarthritis without exocrine pancreatic insufficiency and combination osteoarthritis and exocrine pancreatic insufficiency.
Diagnosis of osteoarthritis was based on diagnostic X-Ray criteria – according J.H. Kellgren and J.S. Lawrence. The level of exocrine pancreatic insufficiency was based on result of Elisa test. State of mineral bone density was examined by using dual-photon densitometry.
Results. It was established the progressive, statistically significant increasing of mineral density of bone tissue in the 1st group patients with osteoarthritis. Patients in the 2nd group, with osteoarthritis in the comorbidity with exocrine pancreatic insufficiency, the densitogram rates were statistically significantly lower than in patients 1st group.
Conclusions. The changes of bone tissue can be explained by the formation of trophological insufficiency as a result of exocrine pancreatic insufficiency. One of the symptoms of trophic failure is bone and mineral changes, in particular, the decrease of bone density.
Key words: osteoarthritis; exocrine pancreatic insufficiency; trophological insufficiency; mineral density of bone tissue.

Lek Obz (Med Horizon), 2020, 69 (1): 7 – 10