Abstract

Objective. Bisphosphonates inhibit bone resorption, cause apoptosis and reduced formation of osteoclasts, and their resorption capacity decreases. They have a high affinity for bone minerals and accumulate mainly in places of osteoclast activity. Highly potent bisphosphonates can lead to osteonecrosis of the jaws due to the toxic effect on soft tissues and bone cells, which is further complicated by infection.

Patients and results. Most cases of osteonecrosis of the jaws occur after a dental procedure that affects the bone or spontaneously. Necrotic bone may remain asymptomatic for a long time, or symptoms may develop, particularly as a result of localized soft tissue inflammation. Treatment depends on age, sex, disease stage, lesion size, comorbidities and medications.

Conclusion. The main goals of treatment are to relieve pain, control infection and stabilize the progression of exposed bone (Fig. 3, Ref. 13). Text in PDF www.lekarskyobzor.sk.

KEY WORDS: osteonecrosis, bisphosphonates, jaws, resorption, infection.

Lek Obz 2022, 71 (10): 399-402

Juraj DEGLOVIČ 1, Marek ŠUPLER 1, Simona DIANIŠKOVÁ 2, Neda MARKOVSKÁ 1

1 Katedra zubného lekárstva LF SZU, Bratislava, prednosta MUDr. J. Deglovič, PhD., MPH
2 Katedra čeľustnej ortopédie SZU, Bratislava, prednostka MUDr. S. Dianišková, PhD., MPH

CITE
DEGLOVIČ J., ŠUPLER M., DIANIŠKOVÁ Neda MARKOVSKÁ N.: Osteonecrosis of the jaws. Lek Obz 2022, 71 (10): 399-402