Abstract 
Introduction. Atrial fibrillation (AF) is the most common persistent arrhythmia in adults worldwide with a prevalence of 2-4% and is the most common arrhythmia in all subtypes of cardiomyopathies (KMP).

Objective. To determine the association of selected morphological, biochemical and genetic parameters of patients with KMP and FP in the region of eastern Slovakia.
Methodology. 6 anthropological, 25 biochemical and 8 physiological and morphological characteristics of the heart were analyzed in all participants. After the analysis of the genetic results, alleles and genotype frequencies were calculated in the patient group and in the control group. Our clinical study was conducted in a group of 85 individuals from the region of eastern Slovakia, of which 43.53% were patients with KMP and FP with an average age of 62.65 ± 11.01 years. The group was dominated by men (64.71%), and there were more frequent patients with dilated KMP as well as persistent AF.
Results. Analysis of anthropometric data confirmed statistically significant differences between the control group and patients with KMP and FP (p  0.05) in all variables except body height. In the case of biochemical parameters, significantly higher average values were confirmed in the control group. A statistically significant correlation was found in relation to KMP with associated AF in the case of left atrial diameter and left ventricular ejection fraction (rpb > 0.8). The representation of potentially risky alleles that are associated with AF was higher in the case of rs13143308 and rs2220427 in patients with KMP and AF compared to the control group.
Conclusion. In our study, the highest associations were confirmed between left atrial diameter and left ventricular ejection fraction in relation to CMP with associated AF. The analysis of selected genetic markers, rs13143308, rs2220427 and rs3853445, located in the 4q25 locus, did not confirm statistically significant associations with KMP and FP (lit. 26).
KEY WORDS: atrial fibrillation, cardiomyopathy, locus, gene, allele, marker.
Lek Obz 2024, 73 (4): 140-147 

Martin Kmec

Kardiocentrum FNsP J.A. Reimana Prešov, primár prof. MUDr. J. Kmec, PhD., MPH