SUMMARY
Autonomic dysfunction is associated with a shift in autonomic balance towards sympathetic dominance, which leads to initation and progression of cardiovascular continuum in the long term. Examination of baroreflex sensitivity (BRS) is a noninvasive marker of autonomic dysfunction. BRS characterises efficacy of blood pressure (BP) regulation in the organism. Autonomic alterations are related to the severity of hypertensive state sharing hypertension induced target organ damage. Critical BRS values < 3 ms/mm Hg in patients with resistant hypertension could identify sympathetic hyperactivity, as well as very high cardiovascular risk in hypertensives and prehypertensives. The pharmacological and nonpharmacological possibilities to influence early functional autonomic dysfunction long before the change of vascular structures present a great challenge. Therefore, restoration of sympatoexcitation in time of socioeconomic stress might be a new strategy for treatment of cardiovascular diseases.

Key word: autonomic nervous system, dysautonomia, sympatho-excitation, arterial hypertension, cardiovascular risk.
Lek Obz, 2020, 69 (9): 319-324

Denisa ČELOVSKÁ, Katarína VLČKOVÁ, Viera ŠTVRTINOVÁ

I. interná klinika, Lekárska fakulta Univerzity Komenského a UNB, Bratislava, prednostka doc. MUDr. S. Kiňová, PhD.

CITE:
Denisa ČELOVSKÁ, Katarína VLČKOVÁ, Viera ŠTVRTINOVÁ: Sympatho-Excitation and Increased Cardiovascular Risk in Hypertensives. Lek Obz, 2020, 69 (9): 319-324