SUMMARY
The incidence of malignant melanoma rose around the world in the last decades ten-fold. In the initial stages a complete surgical excision of the primary tumor with a safety border is a sufficient treatment. In more advanced stages a sentinel lymph node biopsy is indicated. The result is relevant for further treatment and the survival rate. The standard method of lymph node detection is a combination of a radiocoloid and by patent blue coloring. This technique is associated with a higher cost and the need to collaborate with a department of nuclear medicine. Radiation exposure of the staff and the patient and complications with radioactive waste disposal are also negatives of this method. Difficulty of detection in some areas is known as well. Because of these limitations many foreign centers started experimental studies with indocyanine green marking of sentinel lymph nodes. The good tissue penetration properties of indocynanine green, immediate visualisation in the lymph node enables a good detection of sentinel tissue. The absence of radiation makes this a good alternative method for the future. Promising results are achieved in a combination use of radiocoloid and indocyanine green to reduce false negative sentinel lymph node detection.

Key words: malignant melanoma, sentinel lymph node, radiocoloid, indocyanine green, near- infrared light.
Lek Obz, 2021, 70 (4): 150-155

Zuzana ŠIMKOVÁ GABRIELOVÁ 1, Lukáš ŠIMKO 1,2, Pavol MACHO 3, Lucia DEMEŠOVÁ 1

1 Klinika plastickej, rekonštrukčnej a estetickej chirurgie LF UK a Univerzitná nemocnica Bratislava
2 Oddelenie chirurgie ruky, Univerzitná nemocnica Bratislava
3 Abteilung für plastische und rekonstruktive Chirurgie, Allgemeines Krankenhaus Wien

Cite:
ŠIMKOVÁ GABRIELOVÁ Z., ŠIMKO L., MACHO P., DEMEŠOVÁ L.:   Experimental application of indocyanine green in the therapy of malignant melanoma. Lek Obz, 2021, 70 (4): 150-155