SUMMARY
Alzheimer´s disease (AD) is a neurodegenerative disease characterized by progressive dementia. While research in recent decades has brought progress in understanding the pathophysiology of the disease, a definitive diagnostic test other than biopsy is not available. The expected increase in affected individuals in the coming decades requires the development of diagnostic tests applicable to living patients, which require the identification of specific biomarkers of the disease. Analysis of biomarker profiles and subsequent creation of a specific diagnostic panel of AD from blood would allow rapid and non-invasive diagnosis of Alzheimer‘s disease. The present review article describes the currently known biomarkers as well as the latest potentially promising serum molecules, their characteristics and possibilities of use in the diagnosis of AD.

Key words: Alzheimer´s disease, biomarkers, APP, tau-protein, chemokines.
Lek Obz, 2021, 70 (9): 304-309

Petra LAMANCOVÁ 1, Jarmila SZILASIOVÁ 2, Peter URBAN 1

1 Ústav lekárskej a klinickej biochémie, UPJŠ LF, Košice, prednostka prof. Ing. M. Mareková, CSc.
2 Neurologická klinika UPJŠ LF a UNLP, Košice, prednostka prof. MUDr. Z. Gdovinová, CSc., FESO, FEAN

Cite:
LAMANCOVÁ P., SZILASIOVÁ J., URBAN P.: Overview of new and experimental biomarkers of Alzheimer‘s disease. Lek Obz, 2021, 70 (9): 304-309