Abstract
Introduction: The inflammatory response is accepted as an integral part of carcinogenesis. Eosinophils (Eo) are part of the tumor microenvironment as tumor-associated tissue eosinophils (TATE). Tumor Eo exhibit antitumor activity, but can also initiate processes that promote tumorigenesis. The seemingly opposite action of Eo is thought to depend on their interaction with the tumor and other cells in the microenvironment.
Patients and methods: in the pilot study we observed the relationship between numbers of circulating Eo (absolute, relative) and the incidence of distant metastases in a sample of 77 patients with histologically confirmed breast cancer. The presence of metastases was verified by PET-CT scan.
Results: Patients with metastases achieved lower mean values of relative (1.88% vs. 2.17%) and absolute Eo counts (0.13 vs. 0.15 [1 × 109 / l]). The absolute number of Eo appears to be the most promising, although its statistical significance could not be confirmed (AUC = 0.603, p = 0.159).
Conclusions: We assume that there is a relationship between the absolute number of circulating Eo and the presence of metastases in breast cancer. A significant limitation of the study is the relatively small number of enrolled patients and the retrospective nature of the study (Tab. 2, Fig. 1, Ref. 45). Text in PDF www.lekarskyobzor.sk.
KEY WORDS: eosinophilia, breast cancer, metastasis.
Lek Obz 2022, 71 (9): 314-319
Štefan KEČKÉŠ 1, 2, Vladimír BELLA 3, Peter IKHARDT 4, Zuzana ŠIMONÍKOVÁ 1, Július PALAJ 5, Roman ZÁHOREC 6, Gustáv KOVÁČ 2, Štefan DURDÍK 5, Dalibor ONDRUŠ 7
1 Oddelenie hematológie a transfuziológie, Ústav laboratórnej medicíny SZU a OÚSA, Bratislava, primárka MUDr. Z. Šimoníková
2 Ústav chémie, klinickej biochémie a laboratórnej medicíny LF SZU, Bratislava, prednosta prof. MUDr. RNDr. G. Kováč, CSc., MBA
3 Mamologické oddelenie OÚSA, Bratislava, primár doc. MUDr. V. Bella, PhD.
4 Katedra didaktiky prírodných vied, psychológie a pedagogiky PriFUK, Bratislava, vedúci katedry doc. RNDr. Š. Karolčík, PhD.
5 Klinika onkologickej chirurgie LFUK a OÚSA, Bratislava, prednosta prof. MUDr. Š. Durdík, PhD., MHA
6 II. klinika anestéziológie a intenzívnej medicíny LF UK a OÚSA, Bratislava, prednosta doc. MUDr. R. Záhorec, CSc.
7 I. onkologická klinika LFUK a OÚSA, Bratislava, prednosta prof. MUDr. D. Ondruš, DrSc.
CITE:
KEČKÉŠ Š., BELLA V., IKHARDT P., IMONÍKOVÁ Z., PALAJ J., ZÁHOREC R., KOVÁČ G., DURDÍK Š, ONDRUŠ D.: Eosinophil count and breast cancer metastases – pilot study. Lek Obz 2022, 71 (9): 314-319
