SUMMARY
The research team from the Institute of Molecular Genetics of the Czech Academy of Sciences, led by Libor Mac?rek, clarified the role of the hitherto unknown protein called FAM110A in the organization of the dividing spindle, is crucial and elicited a great response. Loss of the FAM110A protein significantly prolonged the duration of mitosis and caused chromosome misalignment leading to severe daughter cell damage. FAM110A has been shown to be abnormally expressed in prostate cancer metastases, where it co-localizes with E-cadherin and b-catenin in junctions in cell adhesion, suggesting a role, resp. involvement of FAM110A in cancer pathogenesis. New findings could be used in the future to control cell division in anticancer treatment.

Key words: FAM110A protein, cell division, mitosis, prostate cancer, breast cancer, anticancer treatment.
Lek Obz, 2021, 70(10): 383-384

Marián BERNADIČ 1,2, Michal BERNADIČ 3

1 Ústav patologickej fyziológie, Lekárska fakulta UK, Bratislava, prednosta prof. MUDr. F. Šimko, PhD., FESC
2 Redakcia časopisu Lekársky obzor, Bratislava, šéfredaktor prof. MUDr. M. Bernadič, CSc.
3 Chirurgická klinika SZU a NOÚ, Bratislava, prednosta prof. MUDr. D. Pinďák, PhD.

Cite:
BERNADIČ M., BERNADIČ M.: FAM110A protein unknown on the scene. Can it help identify the causes of cancer? Lek Obz, 2021, 70(10): 383-384