Investigation of Toll-like receptor 4 levels in patients with respiratory infections with individualized infusion and antimicrobial management

Abstract
The aim of the study is to evaluate the dynamics of TLR-4 levels and microbial colonization in patients with infectious respiratory complications with different treatment strategies.

Materials and Methods. 20 children in each group with different approaches to treatment - in the main observation group in the complex of antimicrobial treatment at the same time with empirically prescribed standard antibiotic therapy we used inhalation of quaternary ammonium compound (decamethoxine) through a nebulizer from the appearance of clinical signs of VAP, and the treatment of patients in the control group was carried out in accordance with generally accepted recommendations with the use of systemic antibacterial and symptomatic therapy.
Results. It was found that the level of TLR-4 in the serum clearly correlates with the dynamics of the infectious process and the microbiological status of patients.
Conclusions. The determination of the level of TLR-4 can serve as a diagnostic criterion for the development of severe bacterial disease and evaluate the effectiveness of the selected treatment regimen (Fig. 6, Ref. 60). Text in PDF www.lekarskyobzor.sk.
KEY WORDS: VAP, children, toll-like receptors 4, quaternary ammonium compound, decamethoxine.

Lek Obz 2023, 72 (6): 260-267

Citácia

NAZARCHUK O., MELNICHENKO M., DMYTRIIEV D. et al.: Výskum úrovní Toll-like receptorov 4 u pacientov s respiranými infekciami s personifikovaným tekutinovým a antimikrobiálnym manažmentom. Lek Obz 2023, 72 (6): 260-267

CITE

NAZARCHUK O., MELNICHENKO M., DMYTRIIEV D. et al.: Investigation of Toll-like receptor 4 levels in patients with respiratory infections with individualized infusion and antimicrobial management. Lek Obz 2023, 72 (6): 260-267

Oleksandr NAZARCHUK 1, Mykola MELNICHENKO 1, Dmytro DMYTRIIEV 1, Nataliia BAHNIUK 1, Bohdan LEVCHENKO 1, Dmytro GREBENIUK 1, Alina DUDAR 1, Oleksandr DOBROVANOV 2,3

1 National Pirogov Memorial Medical University, Vinnytsia, Ukraine
2 A. Getlik Clinic for Children and Adolescents of Slovak Medical University and University Hospital, Bratislava, head doc. MUDr. K. Furkova, CSc.
3 Slovak Medical University, Bratislava, head Dr.h.c. prof. MUDr. P. Šimko, CSc.