Abstract
Background: Psoriasis is a chronic skin disease that affects approximately 2 % to 4 % of the population. In addition to comorbidities such as psoriatic arthritis and cardiovascular disease, it has a negative impact on patients‘ quality of life and is associated with both depression and anxiety. Treatment with biologics improves the physical symptoms of psoriasis and patient adherence. Although biologic treatments change patients‘ lives, how patients perceive these changes is not yet well studied. Therefore, we aimed to determine whether and how the duration of biologic treatment affects the quality of life of psoriasis patients.
Patients and methods: We used an online questionnaire to collect data: 180 respondents with psoriasis who were treated in dermatovenerology outpatient clinics in Martin, Nitra and Banská Bystrica took part in the research. The average age of the patients was 51.46 years. In measuring and evaluating the important factors influencing the quality of life of patients with psoriasis, we used Mann – Whitney test, Pearson Chi-square test, Spearman correlation analysis, linear regression analysis using univariate and multivariate regression models and Kruskal – Wallis test.
Results: The duration of biologic therapy was related to better quality of life for patients. However, more important than how long the disease and treatment lasted was the psychological adjustment of the patients – depression was the most significant factor in reduced quality of life. The degree of experienced anxiety, negative emotions and loneliness were also related to reduced quality of life. Experiencing positive emotions and hope were related to subjectively better quality of life in psoriasis patients.
Conclusion: Our research has shown that psoriasis affects the lives of two-thirds of psoriasis patients. Patients who did not experience any impact of their dermatological disease on their quality of life underwent the longest biological treatment. The highest levels of depression, anxiety and negative emotions were reported by those patients who perceived that psoriasis had an extreme impact on their quality of life (Tab. 3, Fig. 1, Ref. 12). Text v PDF www.lekarskyobzor.sk.
Key words: psoriasis, biologic treatment, quality of life, age.
Lek Obz 2022, 71 (5): 216-219
Igor ROHOŇ 1, Matúš MADLEŇÁK 1, Tatiana HURTOVÁ 1, Martin Jozef PÉČ 2, Mária BREZNICKÁ 1, Juraj PÉČ 1
1 Dermatovenerologická klinika, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, prednosta prof. MUDr. J. Péč, CSc.
2 I. interná klinika, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, prednosta prof. MUDr. M. Mokáň, DrSc., FRCP
Cite:
ROHOŇ I., MADLEŇÁK M., HURTOVÁ T., PÉČ M.J., BREZNICKÁ M., PÉČ J.: Impact of duration of biological treatment on quality of life. Lek Obz 2022, 71 (5): 216-219
