SUMMARY
Ischemia-reperfusion injury is a serious consequence of kidney transplantation. It is a multi-step pathological process in renal tissue that results in graft inflammation. Its clinical consequences are the primary or delayed graft dysfunctions, which result in an increased prevalence of acute renal rejection. Due to increased sensitivity of grafts of cadaveric donors to ischemia-reperfusion injury it is particularly important to understand the basic molecular mechanisms and effects of ischemia and reperfusion on the transplanted graft. At present, the various interventions are used to prevent or treat ischemia-reperfusion injury in order to improve the quality of graft and achieve its longer survival. One of those interventions is ischemic conditioning of donors or recipients of a transplanted kidney, applied before, during or after transplantation. Its positive effect in the process of kidney transplantation has been demonstrated in several experimental and clinical studies.

Key words: ischemia, reperfusion, kidney transplantation, ischemic conditioning.
Lek Obz, 2021, 70 (10): 372-379

Zuzana SZENTESIOVÁ 1, Branislav TREBATICKÝ 2, Jana MUCHOVÁ 1

1 Ústav lekárskej chémie, biochémie a klinickej biochémie, Lekárska fakulta Univerzity Komenského, Bratislava, prednosta
prof. MUDr. L. Turecký, CSc.
2 Urologická klinika Lekárskej fakulty Univerzity Komenského a UN, Bratislava, prednosta Dr.h.c. prof. MUDr. J. Breza, DrSc., MHA

Cite:
SZENTESIOVÁ Z., TREBATICKÝ B., MUCHOVÁ J.: Ischemic conditioning as a prevention against ischemia-reperfusion injury of the kidney during transplantation. Lek Obz, 2021, 70 (10): 372-379