Abstract
Aim: Evaluation of the efficacy of intravenous lidocaine administration during surgical interventions in gynecologic oncology.
Materials and Methods: A single-center randomized study. The study included 170 patients who underwent total hysterectomy or subtotal hysterectomy. The control group (Contr. Gr. ) received anesthesia based on fentanyl, propofol, and atracurium. The intravenous lidocaine administration group (ILA Gr. ) received 1 mg/kg/h lidocaine during anesthesia and 24 hs postoperatively. Final assessment: postoperative pain intensity (NRS), opioid requirement during surgery and postoperatively, stress response assessment, and postoperative sleep quality.
Results: 163 patients completed the study. Two patients in the IV lidocaine group and five patients in the control group were excluded from the analysis. At the time of surgery, the total fentanyl dose was 23 % lower in Contr. Gr. but the severity of the surgical stress response was more prominent in ILA Gr. ; blood glucose levels were 17 % higher in ILA Gr. at the end of surgery compared to Contr. Gr. In the postoperative period, pain intensity according to NRS was not statistically significantly different between the study groups 24 hs after surgery. The quality of sleep was better in ILA Gr. There were no significant differences in the dose of morphine for postoperative anesthesia between the study groups.
Conclusions: Intravenous administration in the perioperative period in patients after gynecologic oncology surgeries did not improve the quality of perioperative anesthesia and did not significantly reduce the dose of opioid analgesics during anesthesia and within a day of the postoperative period (Tab. 2, Fig. 6, Ref. 37). Text in PDF www.lekarsky.herba.sk.
KEY WORDS: intravenous lidocaine infusion, gynecologic oncology surgery, pain, stress response.
Lek Obz 2024, 73 (6): 192-199
Ivan Lisnyy 1, Kristina Zakalska 1, Dmytro DMYTRIIEV 2, Oleksandr DOBROVANOV 3,4, Kostiantyn Sydorenko 1, Yevhenii Horkavyi 1, Andrii Naumenko 1, Volodymyr Pikulskyi 1, Ivan Yegorov 1, Andrii Perkonos 1, Oleksandr Balakhonov 1, Serhii Vorobiov 1, Alla Prokopets 1, Viktoriia Holovko 1, Oleksii Nesterenko 2
1 National Cancer Institute, Anesthesiology and Intensive Care Department, Kyjiv, Ukraine, head prof. I. Lisnyy, MD, PhD
2 National Pirogov Memorial Medical University, Vinnytsya, Ukraine, head prof. V. Petrushenko, MD, PhD
3 A. Getlik Clinic for Children and Adolescents of Slovak Medical University and University Hospital, Bratislava,
head doc. MUDr. K. Furková, CSc.
4 Slovak Medical University, Bratislava, head Dr.h.c. prof. MUDr. P. Šimko, CSc.
