Abstrakt
Úvod: Nesprávne predpisovanie antibiotík v stomatochirurgii vedie k získaniu antibiotickej rezistencie mikroorganizmov.
Cieľ: Vykonať retrospektívnu klastrovú analýzu antibakteriálnych liečiv podľa ich účinnosti proti baktériám izolovaným od pacientov s infekčnými zápalovými ochoreniami mäkkého tkaniva tváre.
Materiály a metódy: Na prierezovej štúdii sa zúčastnilo 351 pacientov, ktorí boli liečení na oddelení maxilofaciálnej chirurgie v rokoch 2019 – 2022.
Výsledky a záver: Podľa výsledkov analýzy izoláty S. aureus izolované z ložísk infekčných a zápalových ochorení mäkkých tkanív tváre zachovávajú citlivos na vankomycín, moxifloxacín, ciprofloxacín, levofloxacín, norfloxacín a cefoxitín. Koaguláza-negatívne Staphylococcus spp. sú najcitlivejšie na norfloxacín, erytromycín, azitromycín, benzylpenicilín, kanamycín, gentamicin, klindamycín a Enterococcus ssp. na norfloxacín a tigecyklín. Rod Kocuria, Rod Streptococcus, drug S. viridans v retrospektívnej analýze zachovali stabilnú citlivos iba na vankomycín (tab. 1, obr. 11, lit. 39). Text v PDF www.lekarsky.herba.sk.
KĽÚČOVÉ SLOVÁ: antibiotiká, rezistencia na antimikrobiálne látky, klinické patogény, stomatochirurgia, faciálna oblasť.
Lek Obz 2024, 73 (9): 318-329
Cluster Analysis Revealed Antibiotics with the Highest Efficacy Against Bacteria Isolated from Patients with Infectious and Inflammatory Diseases of the Soft Tissues of the Facial Area
Abstract
Background: Incorrect prescription of antibiotics in dental surgery leads to the acquisition of antibiotic resistance of microorganisms.
Aim: The aim of the given study was to conduct a retrospective cluster analysis of antibacterial drugs according to their efficacy against bacteria isolated from patients with infectious inflammatory diseases of the facial soft tissue.
Materials and methods: The cross-sectional study involved 351 patients who were treated for in the department of maxillofacial surgery during 2019 – 2022.
Results and conclusions: According to the results of cluster analysis, clinical isolates of S. aureus isolated from foci of infectious and inflammatory diseases of the facial soft tissue retain sensitivity to vancomycin, moxifloxacin, ciprofloxacin, levofloxacin, norfloxacin and cefoxitin. Coagulase-negative Staphylococcus spp. are most sensitive to norfloxacin, erythromycin, azithromycin, benzylpenicillin, kanamycin, gentamicin and clindamycin and Enterococcus ssp. to norfloxacin and tigecycline. Kocuria, Streptococcus, drug S. viridans isolates retained a stable sensitivity only to vancomycin in a retrospective analysis (Tab. 1, Fig. 11, Ref. 39). Text in PDF www.lekarsky.herba.sk.
KEY WORDS: antibiotics, resistance to antimicrobial substances, clinical pathogens, dental surgery, facial area.
Lek Obz 2024, 73 (9): 318-329
Mariia FAUSTOVA 1, Oleksandr NAZARCHUK 2, Halina LOBAN 1, Maiia ANANIEVA 1, Yuliia CHUMAK 1, Kateryna LOKES 3, Bereza YEVHENII 2, Davyd AVETIKOV 3, Marián VIDIŠČÁK 4,5
1 Department of Microbiology, Virology and Immunology, Poltava State Medical University, Ukraine, head prof. H. Loban, MD, PhD.
2 Department of Microbiology, National Pirogov Memorial Medical University, Vinnytsia, Ukraine, head prof. V.P. Kovalchuk, MD, CSc.
3 Department of Surgical Dentistry and Maxillofacial Surgery, Poltava State Medical University, Ukraine, head assoc. prof. K. Lokes, PhD.
4 1stSurgical Clinic of the Slovak Medical University and University Hospital of Medicine, Acad. Ladislav Derer Hospital, Bratislava, head MUDr. I. Brychta, PhD.
5 Slovak Medical University, Bratislava, head Dr.h.c. prof. MUDr. P. Šimko, CSc.